Research projects
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The AGIR laboratory is interested in the development of new anti-infective molecules, possessing specific antimicrobial properties and/or capable of countering the phenomena of resistance linked to a lack of concentration of antibiotics within microorganisms (analogs of siderophores, inhibitors efflux pumps...).
The team's research themes revolve more specifically around 4 groups of infectious agents, found in clinical practice:
1. ESKAPEE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Actinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., Escherichia coli)
2. Mycobacteria (typical and atypical)
3. Plasmodium falciparum
4. BK virus
The team's research themes revolve more specifically around 4 groups of infectious agents, found in clinical practice:
1. ESKAPEE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Actinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., Escherichia coli)
2. Mycobacteria (typical and atypical)
3. Plasmodium falciparum
4. BK virus
A multidisciplinary approach
- Epidemiological and clinical research studies (characterization of the biomolecular targets of epidemic strains),
- Design and synthesis of new antibacterials, antimalarials and antivirals of a heterocyclic and/or peptide nature (siderophore analogues, antimicrobial peptides (AMP), arylamino alcohols, etc.),
- Physicochemical evaluation and study of structure-activity relationships (SAR) in silico,
- In vitro biological evaluation (efficacy, cytotoxicity, transmembrane passage) thanks to the development of cellular models and study of the mechanisms of action using biomolecular approaches (commercial or clinical strains, etc.),
- Biological evaluation ex vivo and in vivo on animal models (efficacy, toxicity, pharmacokinetics, pharmacodynamics).
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