News
* The AGIR laboratory (represented by François HELLE, Etienne BROCHOT, Baptiste DEMEY, Catherine François, Marie PERRET and Laurence MARQUIS) is organizing the 15th Scientific Days of the AFIPP (Francophone Association for the Study of Infections by Papillomaviruses and Polyomaviruses) in Fort-Mahon-Plage from September 27 to 29, 2023. More information is available on the congress website: AFIPP 2023
* The 5th Scientific Day of the AGIR laboratory took place on June 22, 2023 at the UFR de Pharmacie d'Amiens and was an opportunity for discussions on our research work in infectious diseases.
* The laboratory's research work on the development of new anti-virulence agents to counter antibiotic resistance received the prize for best displayed communication entitled
“New 2-heteroaryl-4-aminoquinolines with promising pseudomonal anti-virulence activities” (Marie HANOT, Elodie LOHOU, François PELTIER, Pascal SONNET) during the 30th Young Researchers Day of the SCT (Society of Therapeutic Chemistry).
* The laboratory's research work on the development of new anti-virulence agents to counter antibiotic resistance received the prize for best displayed communication entitled
“Development of new anti-virulence agents to tackle multi-resistant Pseudomonas aeruginosa” (Marie HANOT, Elodie LOHOU, Pascal SONNET) during the 8th international electronic conference in medicinal chemistry (ECMC).
* Morgane CHOQUET obtained the thesis prize from the Sciences Technologies Santé doctoral school (EDSTS) for this doctoral work carried out at the AGIR laboratory, defended on December 17, 2021 and entitled “Molecular characterization of efflux systems in Acinetobacter baumannii and study of new analogue inhibitors of 1-(1-naphthylmethyl)-piperazine”.
* The laboratory's research work on the development of new anti-virulence agents to counter antibiotic resistance received the prize for best displayed communication entitled
“Tackling multi-drug resistance in Pseudomonas aeruginosa thanks to a new promising anti-virulence strategy” (Elodie LOHOU, Marie HANOT, Marine DUPLANTIER, Céline DALLE, Nicolas TAUDON,
Pascal SONNET) during the 2nd international electronic conference on antibiotics (ECA).
* Four professionals from the AGIR team were honored for their commitment from the early hours of the Covid pandemic.
Were named in the new promotion of the Legion of Honor and the National Order of Merit published in the Official Journals on January 1, 2021 and November 24, 2021:
- Pr Claire ANDREJAK, Pulmonologist
- Professor Sandrine CASTELAIN, Virologist
- Ms. Véronique DESCAMPS, Laboratory Technician
- Dr Catherine FRANCOIS, Virologist
A medal ceremony was held for some of the recipients on December 1, 2021 at the Ministry of Solidarity and Health in Paris,
in the presence of Mr. Olivier VÉRAN, Minister of Solidarity and Health.
* The 5th Scientific Day of the AGIR laboratory took place on June 22, 2023 at the UFR de Pharmacie d'Amiens and was an opportunity for discussions on our research work in infectious diseases.
* The laboratory's research work on the development of new anti-virulence agents to counter antibiotic resistance received the prize for best displayed communication entitled
“New 2-heteroaryl-4-aminoquinolines with promising pseudomonal anti-virulence activities” (Marie HANOT, Elodie LOHOU, François PELTIER, Pascal SONNET) during the 30th Young Researchers Day of the SCT (Society of Therapeutic Chemistry).
* The laboratory's research work on the development of new anti-virulence agents to counter antibiotic resistance received the prize for best displayed communication entitled
“Development of new anti-virulence agents to tackle multi-resistant Pseudomonas aeruginosa” (Marie HANOT, Elodie LOHOU, Pascal SONNET) during the 8th international electronic conference in medicinal chemistry (ECMC).
* Morgane CHOQUET obtained the thesis prize from the Sciences Technologies Santé doctoral school (EDSTS) for this doctoral work carried out at the AGIR laboratory, defended on December 17, 2021 and entitled “Molecular characterization of efflux systems in Acinetobacter baumannii and study of new analogue inhibitors of 1-(1-naphthylmethyl)-piperazine”.
* The laboratory's research work on the development of new anti-virulence agents to counter antibiotic resistance received the prize for best displayed communication entitled
“Tackling multi-drug resistance in Pseudomonas aeruginosa thanks to a new promising anti-virulence strategy” (Elodie LOHOU, Marie HANOT, Marine DUPLANTIER, Céline DALLE, Nicolas TAUDON,
Pascal SONNET) during the 2nd international electronic conference on antibiotics (ECA).
* Four professionals from the AGIR team were honored for their commitment from the early hours of the Covid pandemic.
Were named in the new promotion of the Legion of Honor and the National Order of Merit published in the Official Journals on January 1, 2021 and November 24, 2021:
- Pr Claire ANDREJAK, Pulmonologist
- Professor Sandrine CASTELAIN, Virologist
- Ms. Véronique DESCAMPS, Laboratory Technician
- Dr Catherine FRANCOIS, Virologist
A medal ceremony was held for some of the recipients on December 1, 2021 at the Ministry of Solidarity and Health in Paris,
in the presence of Mr. Olivier VÉRAN, Minister of Solidarity and Health.
Seminars
Seminars 2023
Thursday February 16, 1 p.m., room A07, CURS
Aurélien AUBRY
Presentation of his background and his research theme “Study of the genetic variability of the BK virus and the cellular immunity of the host”
Thursday March 2, 1 p.m., thesis room, UFR of Pharmacy
Laurie BIBENS
Presentation of his scientific article currently under review by the publisher: “A review of fatty acid biosynthesis enzyme inhibitors as promising antimicrobial drugs”
Thursday March 23, 1 p.m., thesis room, UFR of Pharmacy
Marie HANOT
Presentation of a scientific article: “Presentation of M64: a Quorum Sensing inhibitor in preclinical development phase”
Thursday March 30, 1 p.m., room A07, CURS
Romain MUSTIERE
Presentation of a scientific article: “Aminopyridines as a preferred motif for the design of antiparasitic molecules”
Thursday April 13, 1 p.m., room A07, CURS
Sara LOPES & Ana-Rita SILVA (Portuguese students hosted at the AGIR laboratory as part of an ERASMUS exchange)
Presentation of their research initiation internship work: “Synthesis and biological evaluation of anti-virulence agents to tackle Pseudomonas aeruginosa” (Sara LOPES)
& “Amplification and titration of stocks of clinical strains of BK virus” (Ana-Rita SILVA)
Thursday May 4, 1 p.m., thesis room, UFR of Pharmacy
Elise CHARRIER
Presentation of a scientific article: “New antimycobacteria molecules targeting MAC in (pre)clinical development phase”
Thursday June 1, 1 p.m., thesis room, UFR of Pharmacy
Sophie DA NASCIMENTO
Presentation of its progress of work: “Peptide synthesis applied to the preparation of polymyxin analogues for antibacterial purposes”
Thursday February 16, 1 p.m., room A07, CURS
Aurélien AUBRY
Presentation of his background and his research theme “Study of the genetic variability of the BK virus and the cellular immunity of the host”
Thursday March 2, 1 p.m., thesis room, UFR of Pharmacy
Laurie BIBENS
Presentation of his scientific article currently under review by the publisher: “A review of fatty acid biosynthesis enzyme inhibitors as promising antimicrobial drugs”
Thursday March 23, 1 p.m., thesis room, UFR of Pharmacy
Marie HANOT
Presentation of a scientific article: “Presentation of M64: a Quorum Sensing inhibitor in preclinical development phase”
Thursday March 30, 1 p.m., room A07, CURS
Romain MUSTIERE
Presentation of a scientific article: “Aminopyridines as a preferred motif for the design of antiparasitic molecules”
Thursday April 13, 1 p.m., room A07, CURS
Sara LOPES & Ana-Rita SILVA (Portuguese students hosted at the AGIR laboratory as part of an ERASMUS exchange)
Presentation of their research initiation internship work: “Synthesis and biological evaluation of anti-virulence agents to tackle Pseudomonas aeruginosa” (Sara LOPES)
& “Amplification and titration of stocks of clinical strains of BK virus” (Ana-Rita SILVA)
Thursday May 4, 1 p.m., thesis room, UFR of Pharmacy
Elise CHARRIER
Presentation of a scientific article: “New antimycobacteria molecules targeting MAC in (pre)clinical development phase”
Thursday June 1, 1 p.m., thesis room, UFR of Pharmacy
Sophie DA NASCIMENTO
Presentation of its progress of work: “Peptide synthesis applied to the preparation of polymyxin analogues for antibacterial purposes”
Participation of the AGIR laboratory in the 1st FHU “RESPIRE” congress
Doctoral graduation ceremony 2021
& Thesis prize from the Sciences Technologies Santé (EDSTS) doctoral school for Morgane CHOQUET
Congratulations to our doctoral student Marie HANOT for this prize obtained during ECMC 2022 promoting our work on the development of new anti-virulence agents to counter antibiotic resistance
Honorary distinctions: Four professionals from the AGIR team were honored for their commitment from the early hours of the Covid pandemic.
Science Festival 2022
The AGIR laboratory is interested in the design, synthesis and biological evaluation of new anti-infectives capable of combating resistance phenomena. Indeed, after revolutionizing modern medicine and considerably increasing life expectancy in developed countries, antibiotic therapy is going through a global crisis in the 21st century due to the appearance of multiple bacterial resistances. In the European Union, antibiotic resistance is in fact responsible for 25,000 deaths per year, with an overall annual cost (prolonged hospitalizations, increased medical expenses, etc.) of 1.5 billion euros for society (source: ECDC 2007) . According to the WHO, the misuse of antibiotics associated with too rare discoveries of new active molecules in recent decades could push us into a post-antibiotic era with dramatic consequences for public health. The fight against resistance phenomena therefore constitutes one of the major challenges of modern antibiotic therapy.
In this context, the team's research themes revolve more particularly around the study of the following infectious agents, found in the clinic:
In this context, the team's research themes revolve more particularly around the study of the following infectious agents, found in the clinic:
- ESKAPEE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Actinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., Escherichia coli)
- Mycobacteria (typical and atypical)
- Plasmodium
- BK virus
- SARS-CoV-2
